ABSTRACT
Objective: To study the chemical constituents of Russula foetens. Methods: The chemical constituents were isolated by repeated silica gel and Sephadex LH-20 column chromatography, and their structures were elucidated by 1H-NMR, 13C-NMR, 2D-NMR (1H-1H COSY, HMQC, HMBC, NOESY), HR-MS, CD, and IR. Results: Eleven compounds were isolated from the fruiting bodies of R. foetens. Of which, six marasmane sesquiterpenes: 8β, 13-dihydroxy-marasm-5β-methoxy γ-acetal (1), 13-hydroxy-marasm-7(8)-en-5-methoxy γ-acetal (2), 8β, 13-dihydroxy-marasm-5-oic acid γ-lactone (3), 8β, 13, 14-trihydroxy- marasm-5-oic acid γ-lactone (4), 7, 8, 13-trihydroxy-marasm-5-oic acid γ-lactone (5), and lactapiperanol A (6); three steroids: (22E, 24R)-ergosta-7, 22-dien-3, 5, 6-triol (7), ergosta-5, 7, 22-trien-3-ol (8), 3-hydroxy-5, 8-epidioxy-ergosta-6, 22-dien (9); and uridine (10), D-allitol (11) were identified. Conclusion: Compounds 1-4, named as russacetal, russacetalen, russunone, and russunoneol respectively, are new compounds isolated from R. foetens. Compounds 7, 8, 10, and 11 in this fungus are first reported.